The Pathophysiology Of Diabetes Mellitus Type 1 And 2

The Pathophysiology of Diabetes Mellitus Type 1 and 2 According to the National Diabetes Statistics Report from The Centers for Disease Control and Prevention in 2012, it revealed that 29.1 million of the American population has diabetes with 1.7 million new diagnoses each year. Diabetes is the seventh leading cause of death in the United States and costs over 176 billion dollars per year. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to the dysfunction of the pancreas. The two most common categories of diabetes mellitus are type 1 and type 2 (Huether McCance, 2012). In order to understand the differences and similarities between type 1 and type 2, the pathophyisology, assessment findings, and treatments of each type will be examined. Pathophysiology of Type 1 Diabetes Mellitus Type 1 diabetes is due to the autoimmune destruction of beta-cells. Within the pancreas, one of the cell types in the islets of Langerhans is beta cells. These beta cells are responsible for releasing insulin to regulate normal blood sugar levels. Although the mechanisms of beta cell destruction are not completely clear, it is suspected that individuals with type 1 have interferon-alpha expression due to a viral infection, which may cause the hyperexpression of class 1 major histocompatibility complex (MHC) molecules by beta cells (Richardson, Morgan, Foulis 2014). The class 1 MHC molecules are markers to help cytotoxic CD8 T-cells to recognize and destroyShow MoreRelatedEssay on Diabetes Mellitus1381 Words   |  6 Pages1. Discuss the pathophysiology of Diabetes Mellitus. Diabetes Mellitus is a chronic condition in which the body has the inability to produce insulin or react normally to insulin. The pathophysiology of diabetes mellitus is extremely complex, as diabetes mellitus is characterized by different types but share common symptoms and complications. Diabetes mellitus is classified in two types: Type 1 and type 2 diabetes. Although the disease is characterized by different etiologiesRead MorePathophysiology Of Diabetes Mellitus And Diabetes Essay1189 Words   |  5 PagesPathophysiology of Diabetes Mellitus Diabetes Mellites(DM), is a deficiency of insulin action causing hyperglycemia. The majority of DM have a decreased secretion of the cells, insulin resistance, or counterregulatory hormones( McPhee Hammer, 2010). Insulin is synthesized from the beta cells from the pancreases. Composed from A peptide and B peptide connected to C peptide and disulfide bonds. Insulin is a hormone that aids in metabolism. encourages glucose uptake and the synthesis works mainlyRead MoreRenal Microvascular Complications Of Type 2 Diabetes Essay1105 Words   |  5 PagesMicrovascular Complications of Type 2 Diabetes: Aetiology and Pathogenesis Abstract There have been a number of manuscripts reporting on the association of complications in type 2 diabetes with high glucose blood levels, high levels of C-Peptide, high advanced glycation end products (AGEs) and vascular cell adhesion molecule-1 (VCAM-1) and oxidative stress. In order to further investigate the aetiology and pathophysiology of renal microvascular complications in type 2 diabetes, papers were reviewed throughRead MoreDiabetes The Endocrine System Consists Of Elevated Or Inadequate Depression Of Endocrine Gland753 Words   |  4 PagesDiabetes In diabetes the endocrine system comprises of elevated or inadequate depression of endocrine gland with results in alterations in hormone levels. â€Å"Diabetes affect 25.8 million people, or 8.3% the U.S. population, have diabetes and another seven million are estimated to be undiagnosed† (Huether McCance, 2012, P.447). Diabetes Insipidus â€Å"Diabetes Insipidus (DI) is a disorder of insufficient activity of ADH, leading to polyuria (frequent urination) and polydipsia (frequent drinking)† (HuetherRead MoreInvestigating The Aetiology And Pathophysiology Of Renal Microvascular Complications1094 Words   |  5 Pagescomplications in type 2 diabetes with high glucose blood levels, high levels of C-Peptide, high advanced glycation end products (AGEs) and vascular cell adhesion molecule-1 (VCAM-1) and oxidative stress. In order to further investigate the aetiology and pathophysiology of renal microvascular complications in type 2 diabetes, papers were reviewed through 2000 using the NIH PubMed Literature Search System. Inclusion criteria were that manuscripts 1) be primary peer-review research article; 2) conciselyRead MorePathophysiology Of Diabetes Mellitus And Mellitus1706 Words   |  7 Pages Diabetes Mellitus Nathalie Dao Med 2056 VN FT030 Diabetes Mellitus Research Paper Ms. Annabelle Anglo 3/16/2015 â€Æ' EXPLANATION OF PATHOPHYSIOLOGY The pathophysiology of the two types of Diabetes Mellitus are described by Schilling (2010). Type 1 Non-Insulin Dependent Diabetes Mellitus starts with a viral infection or other triggering condition that forms antibodies that destroy the beta cells within the pancreas. This causes the pancreas’ production of insulin to drop over time. InitiallyRead MoreA Short Note On Diabetes Mellitus And Diabetes1738 Words   |  7 PagesDIABETES MELLITUS 1 Emily Marroquin MED 2056 Diabetes Mellitus Instructor Michela Leytham 12/3/14 DIABETES MELLITUS 2 In 2012 29.1 million Americans had diabetes of those 29.1 million, 21.0 million were diagnosed and 8.1 million were undiagnosed. What isRead MoreEndocrine Research Paper Pathophysiology: Diabetes Mellitus1384 Words   |  6 Pagespopulation)(Diabetes Facts). When people think about epidemics that affect the world today, the first ones that usually come to mind are those that kill of millions of people every year such as HIV, malaria, or the influenza. There are even those that haven’t been as deadly but have gained extreme notoriety such as the H1N1 virus, cholera, and anthrax. For this paper forget about HIV, H1N1, cholera, and the influenza; introducing Diabetes mellitus: a silent epidemic. Diabetes mellitus or commonlyRead More Diabetes Mellitus Essay examples1745 Words   |  7 PagesDiabetes mellitus (DM) or simply diabetes, is a chronic health condition in which the body either fails to produce the amount of insulin needed or it responds inadequately to the insulin secreted by the pancreas. The three primary types of diabetes are: Diabetes Type 1 and 2, and during some pregnancies, Gestational diabetes. The clichà © for all three types of diabetes is high glucose blood levels or hyperglycemia. The pathophysiology of all types of diabetes mellitus is related to the hormone insulinRead MoreDiabetes And Drug Treatment Of Diabetes799 Words   |  4 PagesDiabetes and Drug Treatments Diabetes represents one of the most challenging disorders facing the United States population. Diabetes can be classified as Diabetes Mellitus type I, Diabetes Mellitus type II, Gestational Diabetes, and secondary diabetes from other conditions. At least 90% of diabetes is type 2, and the complications could be avoided by carefully managing hyperglycemia, hypertension and dyslipidemia (Wilbur, 2013). Therefore, the healthcare industry is spending vast amounts of time